SnapShot: Hox Gene Regulation
نویسندگان
چکیده
d12 d13 d10 d11 d11 d13 d11 d10 d9 d8 d4 d3 d1 d12 c13 c11 c10 c9 c6 c5 c4 c12 c8 b13 b9 b7 b6 b5 b4 b3 b2 b1 b8 a13 a11 a10 a9 a7 a6 a5 a4 a3 a2 a1 HoxA HoxB HoxC d13 d11 d10 d9 d8 d4 d3 d1 d12
منابع مشابه
Global down-regulation of HOX gene expression in PML-RARalpha + acute promyelocytic leukemia identified by small-array real-time PCR.
Acute promyelocytic leukemia (APL) is associated with a reciprocal and balanced translocation involving the retinoic acid receptor-alpha (RARalpha). All-trans retinoic acid (ATRA) is used to treat APL and is a potent morphogen that regulates HOX gene expression in embryogenesis and organogenesis. HOX genes are also involved in hematopoiesis and leukemogenesis. Thirty-nine mammalian HOX genes ha...
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Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns, the disruption of which can lead to developmental defects and disease. Here, we examine the spectrum of molecular mechanisms controlling Hox gene...
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Hox genes have a well-characterized role in embryonic development, where they determine identity along the anteroposterior body axis. Hox genes are expressed not only during embryogenesis but also in the adult, where they are necessary for functional differentiation. Despite the known function of these genes as transcription factors, few regulatory mechanisms that drive Hox expression are known...
متن کاملComparative Analysis of Hox Gene Expression in the Polychaete Chaetopterus: Implications for the Evolution of Body Plan Regionalization1
SYNOPSIS. The Hox genes are widely regarded as candidates for involvement in major evolutionary changes in body plan organization. We examine Hox gene expression data for several taxa, in relation to recent work on the polychaete annelid Chaetopterus. The work in Chaetopterus shows the basic conservation of colinearity of anterior expression boundaries seen in other groups. It also reveals nove...
متن کاملMoD Special issue on “Upstream and Downstream of Hox Genes
The antero-posterior axis of bilaterian is determined by set of homeodomain transcription factors encoded by the hox genes that are organized into gene clusters. Remarkably, the arrangement of the hox genes along the chromosome within the cluster corresponds to the order of the structures that are specified along the antero-posterior body axis of the organism. This conserved organization is tho...
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ورودعنوان ژورنال:
- Cell
دوره 156 شماره
صفحات -
تاریخ انتشار 2014